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目的探讨尿微量排泄蛋白与肾移植的关系。方法应用免疫散射测浊技术检测了30例肾移植患者四种特定尿微量蛋白：尿微量白蛋白（UAIB）、尿转铁蛋白（UTf）、尿al－微球蛋白（Ual－M）、尿免疫球蛋白G（UIgG）。结果除UIgG外，特定蛋白UALB、Ual－M与UTf均与血清肌酐（Scr）呈显著正相关。动态观察到Scr升高前1周左右，在常规蛋白尿尚不明显时，特定尿微量蛋白已开始出现异常，并于Scr增高期间达到高峰。肾移植急性排异以UALB增幅最大（207.5±112.7mg／L），而慢性环泡霉素A（CSA）肾中毒则以Ual－M增高为主（95.0±34.1mg／L）。结论特定尿微量蛋白变化与移植肾功能密切相关，对移植后并发症的鉴别有一定帮助。
Objective To investigate the relationship between urinary excretion of excreted protein and renal transplantation. Methods The specific urinary microalbuminuria (UAIB), urinary transferrin (UTf), urinary al-microglobulin (Ual-M), urine Immunoglobulin G (UIgG). Results In addition to UIgG, the specific proteins UALB, Ual-M and UTf were positively correlated with serum creatinine (Scr). Dynamically observed about 1 week before the increase of Scr, when the routine proteinuria is still not obvious, the specific urine micro-protein has begun to appear abnormal and reached a peak during the increase of Scr. Acute renal allograft rejection increased most with UALB (207.5 ± 112.7 mg / L), while chronic cyclosporin A (CSA) nephrotoxicity increased with Ual-M (95.0 ± 34.1 mg / L). Conclusion The changes of specific microalbuminuria are closely related to the function of renal allograft and may be helpful in the differential diagnosis of posttransplantation.