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Notch信号通路活化可促进乳腺癌的形成和进展,上皮间质转化的发生可促进乳腺癌的侵袭和迁移。本文就Notch信号通路与上皮间质转化的相关性及在乳腺癌发生、发展中的作用和机制作一综述。
Notch signaling pathway can promote the formation and progression of breast cancer, and the occurrence of epithelial-mesenchymal transition can promote the invasion and migration of breast cancer. This article reviews the relationship between Notch signaling pathway and epithelial-mesenchymal transition and its role in breast carcinogenesis and development.