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目的 :观察对Hp阳性消化性溃疡患者采用抗菌药物和抑制胃酸分泌药物联合治疗的临床效果。方法 :将我院在2014年4月~2015年10月期间收治的100例Hp阳性消化性溃疡患者随机分为观察组和对照组各50例,对照组患者给予传统西药治疗,观察组患者给予抗菌药物和抑制胃酸分泌药物联合治疗,比较两组患者的治疗有效率、幽门螺旋杆菌清除率以及治疗前后的症状评分。结果:观察组治疗有效率为94.00%,对照组治疗有效率为78.00%,组间差异有统计学意义(P<0.05);观察组幽门螺旋杆菌清除率为86.00%,对照组幽门螺旋杆菌清除率为62.00%,组间差异有统计学意义(P<0.05);治疗后观察组患者症状评分显著优于对照组,差异有统计学意义(P<0.05)。结论:抗菌药物联合抑制胃酸分泌药物治疗消化性溃疡能显著改善患者的临床症状,清除幽门螺旋杆菌,疗效明确。
Objective: To observe the clinical effect of anti-bacterial drugs and gastric acid-secreting drugs in patients with Hp-positive peptic ulcer. Methods: 100 cases of Hp-positive peptic ulcer patients admitted to our hospital from April 2014 to October 2015 were randomly divided into observation group and control group, 50 cases in each group. Patients in control group were treated with traditional western medicine and those in observation group were given Antibacterial drugs and inhibition of gastric acid secretion drug combination therapy, the treatment of patients in both groups efficiency, clearance rate of Helicobacter pylori and symptom scores before and after treatment. Results: The effective rate was 94.00% in the observation group and 78.00% in the control group, with a significant difference between the two groups (P <0.05). The clearance rate of H. pylori in the observation group was 86.00%. The control group had H. pylori eradication The difference was statistically significant (P <0.05). The symptom score of the observation group was significantly better than that of the control group after treatment, the difference was statistically significant (P <0.05). Conclusion: The combination of antibacterial drugs and gastric acid secretion drugs in the treatment of peptic ulcer can significantly improve the clinical symptoms of patients with Helicobacter pylori eradication, the curative effect is clear.