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目的:观察自体外周血干细胞支持下行中高剂量化疗对急性髓系白血病(AML)的疗效。方法:40例处于完全缓解(CR)的AML患者,14例(治疗组)行中高剂量化疗后回输自体外周血干细胞,观察与进行自体移植的26例(对照组)患者疗效有无差异。结果:至随访结束,治疗组3例复发,3例死亡,11例仍存活(10例无复发存活),两组复发率及3年无病生存率(LFS)差异均有统计学意义(P﹤0.05)。结论:该疗法可降低AML复发率,延长患者LFS。
Objective: To observe the efficacy of autologous peripheral blood stem cells in supporting high-dose chemotherapy for acute myeloid leukemia (AML). METHODS: Forty patients with AML who were in complete remission (CR) and 14 patients (treatment group) were treated with high-dose chemotherapy and received autologous peripheral blood stem cells. Observed whether there were differences in the efficacy of 26 autologous transplantation (control) patients. Results: At the end of follow-up, 3 patients in the treatment group relapsed, 3 died, and 11 patients survived (10 patients survived without recurrence). The relapse rate and 3-year disease-free survival rate (LFS) of the two groups were statistically significant (P<0.05). <0.05). Conclusion: This therapy can reduce the relapse rate of AML and prolong the patient’s LFS.