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目的调查喀什地区女性人群宫颈脱落细胞HPV感染情况、亚型分布及其特点。方法收集1 548例女性的宫颈脱落细胞标本,采用PCR-反向点杂交法检测23种HPV基因型,对HPV感染情况及其型别进行分析。结果 HPV感染阳性率为33.3%(485/1 548),其中HPV-16感染率19.4%;HPV42感染率10.3%;HPV52感染率9.9%;HPV58感染率7.6%;HPV53感染率7.2%;单一亚型感染率66.8%,多重感染率33.2%;41~50岁的女性人群中HPV感染率最高(43.3%),高于其他年龄组,且差异具有统计学意义(P<0.05)。结论喀什地区女性人群HPV感染以HPV16型为主,而且41~50岁的女性人群中HPV感染率最高,为喀什地区相关部门HPV的预防控制工作提供理论依据。
Objective To investigate the HPV infection, subtypes and characteristics of cervical exfoliated cells in female population in Kashi area. Methods A total of 1 548 female specimens of cervical exfoliated cells were collected. The genotypes of 23 HPVs were detected by PCR-reverse dot blot hybridization, and the HPV infection and its type were analyzed. Results The positive rate of HPV infection was 33.3% (485/1 548), among which HPV-16 infection rate was 19.4%, HPV42 infection rate was 10.3%, HPV52 infection rate was 9.9%, HPV58 infection rate was 7.6%, HPV53 infection rate was 7.2% The infection rate was 66.8% and the multiple infection rate was 33.2%. The prevalence of HPV infection was the highest among female population aged 41-50 years (43.3%), which was higher than other age groups (P <0.05). Conclusion The HPV infection in female population in Kashi Prefecture is mainly HPV16, and the highest infection rate among the female population aged 41-50 years provides theoretical basis for the prevention and control of HPV in relevant departments in Kashgar region.