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目的:从形态学角度观察血管内皮细胞生长因子（VEG）在机械性TMR（transmyocardialrevascularization）管道内促血管再生与重建的作用。方法:利用高速空心钻头在家兔左室前壁进行TMR,形成透室壁性心肌管道。实验组的TMR管道内注射VEGF;对照组仅做单纯机械性TMR。动物术后不同时间处死,利用组织切片染色法,对照观察实验组和对照组TMR管道内血管再生与重建的状况。结果:术后2周,实验组和对照组的TMR管道内新生小血管的密度/数量分别为（24.20±0.98）条/10 ×4倍和（8.41±0.59）条/10×4倍,P<0.001;术后6～8周,分别为（11.08±0.96）条/10×4倍和（3.31±0.57）条/10×4倍,P<0.001。结论:VEGF对机械性TMR管道内血管的再生与重建具有非常明显的促进作用。
OBJECTIVE: To observe the role of vascular endothelial growth factor (VEG) in promoting vascular regeneration and remodeling in mechanical TMR (transmyocardialrevascularization) tube from the morphological point of view. Methods: TMR was performed on the anterior wall of rabbit left ventricle by using a high speed hollow drill to form a transmural myocardial duct. Experimental group of TMR pipe injection of VEGF; control group only a simple mechanical TMR. The animals were sacrificed at different times after operation. Tissue sections were used to observe the status of vascular regeneration and reconstruction in TMR ducts of experimental and control groups. Results: At 2 weeks after operation, the density and number of newborn small vessels in TMR group were (24.20 ± 0.98) / 10 × 4 times and (8.41 ± 0.59) / 10 × 4 times, respectively, P <0.001; 6 to 8 weeks postoperatively, they were (11.08 ± 0.96) / 10 × 4 times and (3.31 ± 0.57) / 10 × 4 times respectively, P <0.001. Conclusion: VEGF plays a very significant role in the regeneration and reconstruction of vessels in mechanical TMR.