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目的探讨2型糖尿病合并代谢综合征理想的胰岛素强化治疗方案。方法82例新诊断的2型糖尿病合并代谢综合征患者,给予胰岛素强化治疗。治疗方案:用胰岛素泵连续皮下注射(CSII组)16例,三餐前使用速效胰岛素类似物针皮下注射(A组)24例,三餐前使用速效胰岛素类似物针,夜间10时使用中效胰岛素皮下注射(B组)42例。结果三组均可使血糖显著下降(P<0.01),平均达标天数:CSII组:(8.8±3.5)d,A组:(12.6±2.6)d,B组:(13.2±3.8)d;低血糖发生情况:CSII组5例(占31.25%),A组2例(占8.3%),B组15例(占35.7%)。结论CSII组可较快控制血糖,A组低血糖发生机率较低,胰岛素用量最少。
Objective To investigate the ideal insulin intensive treatment for type 2 diabetes with metabolic syndrome. Methods A total of 82 newly diagnosed type 2 diabetic patients with metabolic syndrome were given intensive insulin therapy. Treatment regimen: Sixteen consecutive subcutaneous injections with insulin pump (CSII group), 24 subcutaneously with a fast-acting insulin analogue needle (A group) before meals, a fast-acting insulin analogue needle three meals prior to midnight Subcutaneous injection of insulin (B group) 42 cases. Results The blood glucose levels were significantly decreased in all three groups (P <0.01). The mean number of days reached the standard was (8.8 ± 3.5) days in CSII group, (12.6 ± 2.6) days in group A and (13.2 ± 3.8) days in group B Blood glucose: CSII group 5 cases (31.25%), A group 2 cases (8.3%), B group 15 cases (35.7%). Conclusion The CSII group can control blood sugar faster, the incidence of hypoglycemia in group A is lower, and insulin dosage is the least.