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目的研究瘦素在结直肠癌组织中的表达情况及其与结直肠癌临床病理特征的关系,从而评价瘦素在结直肠癌发生发展中作用。方法采用免疫组织化学方法分别检测瘦素在66例结直肠癌、23例腺瘤性息肉及10例正常结肠粘膜组织三组中的表达情况及其与结直肠癌临床病理特征的关系。结果瘦素在结直肠癌、结直肠腺瘤性息肉及正常结肠粘膜组织中的表达率分别为50.0%、30.4%、0%,瘦素在结直肠癌中阳性表达明显高于息肉组及正常组(P<0.01),而在息肉组及正常组中的表达差异无统计学意义(P>0.05);瘦素表达与患者性别、年龄、肿瘤大小、分布部位、分化程度、有无淋巴结转移、有无远处转移及TNM分期等临床病理特征无关(P>0.05)。结论瘦素表达从正常结肠粘膜、结直肠息肉至结直肠癌呈逐渐增加的趋势;瘦素表达与结直肠癌的发生、发展中可能起了一定作用。
Objective To study the expression of leptin in colorectal cancer and its relationship with the clinicopathological features of colorectal cancer so as to evaluate the role of leptin in the development of colorectal cancer. Methods Immunohistochemistry was used to detect the expression of leptin in 66 cases of colorectal cancer, 23 cases of adenomatous polyps and 10 cases of normal colonic mucosa tissues and their relationship with the clinicopathological features of colorectal cancer. Results The expression rates of leptin in colorectal cancer, colorectal adenomatous polyps and normal colorectal mucosa were 50.0%, 30.4% and 0%, respectively. The positive expression of leptin in colorectal cancer was significantly higher than that in polyps and normal (P <0.01), but there was no significant difference between the polyp group and the normal group (P> 0.05). The expression of leptin correlated with the gender, age, tumor size, distribution, differentiation, lymph node metastasis , With or without distant metastasis and TNM staging clinical pathological features (P> 0.05). Conclusion The expression of leptin tends to increase from normal colorectal mucosa, colorectal polyps to colorectal cancer. Leptin expression may play a role in the occurrence and development of colorectal cancer.