在Ｄ半乳糖所致小鼠亚急性损伤引起衰老的模型上，以脑内ＭＡＯＢ活性和尾腱中羟脯氨酸（Ｈｙｐ）含量为指标，检测了灵芝的作用。结果Ｄ半乳糖可明显提高实验小鼠ＭＡＯＢ的活性和Ｈｙｐ含量，而２５０ｍｇ／ｋｇ和５００ｍｇ／ｋｇ的灵芝可有效的抑制Ｄ半乳糖的作用，降低ＭＡＯＢ的活性和Ｈｙｐ含量，并呈一定的剂量依赖性关系 In Dgalactose induced subacute mice caused by aging model, MAO  B activity in the brain and tail hydroxyproline hydroxyproline (Hyp) content as an indicator to detect the effect of Ganoderma lucidum. Results D  galactose can significantly improve the activity of mice MAO  B and Hyp content, and 250mg / kg and 500mg / kg of Ganoderma lucidum can effectively inhibit the role of D  galactose and reduce MAO  B activity and Hyp content , And showed a certain dose-dependent relationship