程序性细胞死亡是一种程序化的主动性细胞死亡,半胱胺酸天冬氨酸特异性蛋白酶家族(在该过程中起着不可忽视的作用。基于Caspase在程序性细胞死亡过程中所起的作用,将程序性细胞死亡分为两大类:Caspase依赖型和Caspase非依赖型。前者即典型的凋亡,后者包括自体吞噬、副凋亡、有丝分裂灾变、凋亡样程序性死亡、坏死样程序性死亡等。这些Caspase非依赖型的细胞程序性死亡途径与生理及病理现象密切相关。 Programmed cell death is a programmed pro-active cell death that plays an important role in the process of caspase-based proteases (based on the role of Caspase in programmed cell death , Which classified apoptosis into two major groups: Caspase-dependent and Caspase-independent, the former being typical of apoptosis, the latter including autophagy, accessory apoptosis, mitotic catastrophe, apoptotic apoptosis, Necrosis-like programmed death, etc. These caspase-independent apoptotic pathways are closely related to physiological and pathological phenomena.