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血-脑屏障与血-脑脊液屏障是不同的,因此抗菌素在脑脊液中的浓度不能用以计算脑组织或颅内脓液的药物浓度。为评价何种抗菌素最适于颅内脓肿治疗,作者对32例患者的颅内脓液及血清标本测定下列抗菌素的浓度:青霉素、氨苄青霉素、邻氯青霉素、头孢菌素Ⅱ、庆大霉素、氯霉素、褐霉酸和林可霉素。应用青霉素的23例患者中17例在其脓液或/和血清中测得青霉素,说明青霉素透入脓肿较好,不能测得者有的是由于致病菌产生β-内酰胺酶,因此青霉素在血清和脓液中浓度波动很大,据临床反应判断每
The blood-brain barrier is different from the blood-cerebrospinal fluid barrier, so the concentration of antibiotics in the cerebrospinal fluid can not be used to calculate the drug concentration in brain tissue or intracranial pus. To evaluate which antibiotic is best suited for intracranial abscess treatment, the authors determined intracranial pus and serum samples from 32 patients for the following antibiotic concentrations: penicillin, ampicillin, cloxacillin, cephalosporin II, gentamicin , Chloramphenicol, fusidic acid and lincomycin. 17 cases of penicillin in 23 patients in its pus and / or serum measured penicillin, penicillin penetrating abscess better, can not be measured due to some pathogens produce β-lactamase, so penicillin in serum And pus concentration fluctuations, according to the clinical response to determine each