为了解我国内蒙古通辽和吉林长春地区宫颈癌中HPV16亚型的分布情况,对通辽和长春的30例HPV16阳性宫颈癌样品中的HPV16 E6基因进行序列分析.结果在30例宫颈癌样品中的E6全长基因内发现11处位点突变,形成了14种突变体,其中突变T459G是本试验第一次发现的突变.经系统进化分析发现,所有突变体均属欧洲原型突变群.结合之前我国HPV16亚型分布调查结果表明,欧洲型和东亚型HPV16在我国不同地区,分布不均一,主要以欧洲原型突变群为主. In order to understand the distribution of HPV16 subtypes in cervical cancer of Tongliao and Changchun in Inner Mongolia of China, the HPV16 E6 gene in 30 HPV16 positive cervical cancer samples of Tongliao and Changchun was sequenced.Results In 30 cervical cancer samples, E6 Eleven locus mutations were found in the full-length gene, forming 14 kinds of mutants, of which the mutation T459G is the first mutation found in this experiment.According to the phylogenetic analysis, all the mutants are the European prototype mutation group. The distribution of HPV16 subtypes showed that the European and East Asian HPV16 were unevenly distributed in different regions of China, mainly based on the European prototype mutation population.