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目的 :观察降纤酶治疗不同时期脑梗死的疗效。方法 :注射用降纤酶 (国产力源精纯溶栓酶 )治疗发病 >2 4h～ 30天的脑梗死 73例 ,并随机选择同期住院的脑梗死 4 0例 ,予川芎嗪治疗为对照组。进行疗效评定 ,并观察用药前后血纤维蛋白原(FIB)、凝血酶原时间 (PT)、凝血酶时间 (TT)、肝肾功能变化。结果 :治疗前、后脑梗死急性期与慢性期组神经功能缺损程度评分及日常生活能力状态 (Barthel指数 )评分差异均有显著性 (P <0 .0 0 1) ,降纤酶组疗效优于对照组 (P <0 .0 5 )。治疗后血FIB显著降低 (P <0 .0 1) ,而PT、TT、肝肾功能无明显变化 (P >0 .0 5 )。结论 :降纤酶对发病 >2 4h～ 30天左右的急、慢性脑梗死仍有较好的疗效 ,且副作用少。
Objective: To observe the effect of defibrase on cerebral infarction in different periods. Methods: 73 cases of cerebral infarction with onset of> 24 hours to 30 days were treated with defibrinogen for injection (domestic Liyuan pure thrombolytic enzyme) and 40 cases of cerebral infarction were randomly selected in the same period of hospitalization, and treated with ligustrazine . The curative effect was evaluated and the changes of fibrinogen (FIB), prothrombin time (PT), thrombin time (TT) and liver and kidney function were observed before and after treatment. Results: The scores of neurological impairment and Barthel index in the acute and chronic cerebral infarction patients before and after treatment were significantly different (P <0.01), and the defibrase activity was better than that of the defibrase group Control group (P <0.05). After treatment, blood FIB was significantly lower (P <0.01), while PT, TT, liver and kidney function had no significant change (P> 0.05). Conclusion: Defibrase has good curative effect on acute and chronic cerebral infarction with incidence> 24 hours to 30 days with few side effects.