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在早期的有关研究中,出现的汞暴露程度与尿汞浓度间的个体差异,其原因不仅是由于工人个体间的生物学差异,而且也由于采样方案不恰当。因为当时的采样方案不是根据有关汞排泄动力学的明确概念进行设计的。 近十几年,学者们对汞吸收与排泄的动力学进行了研亢。Teisinger研究了数名志愿者对汞蒸气的吸收。当暴露于100μg/m~3 7小时,汞蒸气的平均储留为76％,肺泡气内几乎检测不出汞。暴露后呼吸气内的汞迅速地呈指数性下降(半衰期约为1分钟),尿汞量很少超过正常值。结论认为,汞的排泄是缓慢的、不规则的,汞的排泄并不反映吸收的剂量。
In earlier studies, the individual differences between mercury exposure and urinary mercury concentrations were due not only to the biological differences among workers but also to inappropriate sampling protocols. Because the then sampling plan was not based on a clear concept of mercury excretion dynamics. In recent decades, scholars have studied the kinetics of mercury absorption and excretion. Teisinger studied the absorption of mercury vapor by several volunteers. When exposed to 100 μg / m 3 for 7 hours, the average mercury vapor storage was 76% and almost no mercury was detected in the alveolar gas. Mercury in the respiratory gas exponentially declines after exposure (half-life is about 1 minute) and the amount of mercury in the urine rarely exceeds normal. The conclusion is that the mercury excretion is slow, irregular, mercury excretion does not reflect the absorbed dose.