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目的探讨晚发性维生素K缺乏症的临床情况。方法回顾性分析45例晚发性维生素K缺乏症的临床表现、病因及预后。结果45例晚发性维生素K缺乏症患儿发生颅内出血41例(91.1%%),死亡3例(6.7%)。随访27例,智力低下12例(45.6%),肢体功能障碍15例(55.6%)。结论晚发性维生素K缺乏症颅内出血发生率高,致残率高,应积极有效开展预防工作。晚发性维生素K缺乏症与母乳喂养、维生素K吸收障碍有关。
Objective To investigate the clinical situation of late onset vitamin K deficiency. Methods The clinical manifestations, etiology and prognosis of 45 patients with late onset vitamin K deficiency were retrospectively analyzed. Results 45 cases of delayed vitamin K deficiency in children with intracranial hemorrhage occurred in 41 cases (91.1 %%), 3 patients died (6.7%). Follow-up in 27 cases, mental retardation in 12 cases (45.6%), limb dysfunction in 15 cases (55.6%). Conclusions The incidence of intracranial hemorrhage of late onset vitamin K deficiency is high and the morbidity is high. Prevention should be actively and effectively carried out. Late-onset vitamin K deficiency is associated with breastfeeding and vitamin K malabsorption.