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DM2患者40例及正常对照者(NC)25人,行标准餐实验,测定Leptin及空腹、餐后0.5小时、餐后2小时血糖(Plasma glucose,PG)及胰岛素(insulin,Ins),同时测定甘油三酯(TG)、胆固醇(CH)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及糖化血红蛋白(HbA1c)。初诊DM2患者30例给予二甲双胍0.5bid治疗12周,复查上述指标,观察其变化。结果与NC组相比,DM2组Leptin水平明显升高(P<0.05),且女性患者高于男性(P<0.05),肥胖患者高于非肥胖者。二甲双胍治疗12周后DM2组FPG、0.5hPG、2hPG、HbA1c、TG、CH、HOMA-IR、Leptin均显著降低(P均<0.05),HDL-C升高(P<0.05)。结论二甲双胍治疗12周后,DM2患者FPG、0.5hPG、2hPG、HbA1c、TG、CH、HOMA-IR、Leptin均显著降低,HDL-C升高。
40 patients with DM2 and 25 normal controls (NC) underwent standard-meal test. The levels of Leptin, fasting blood glucose, postprandial 0.5 hour, postprandial plasma glucose (PG) and insulin (Ins) TG, CH, LDL-C, HDL-C and HbA1c were measured. 30 newly diagnosed DM2 patients were given metformin 0.5bid for 12 weeks, and the above indexes were reviewed to observe the changes. Results Compared with NC group, Leptin level in DM2 group was significantly higher than that in NC group (P <0.05). Female patients were higher than male ones (P <0.05), obese patients were higher than non-obese ones. The levels of FPG, 0.5hPG, 2hPG, HbA1c, TG, CH, HOMA-IR and Leptin in DM2 group were significantly decreased (all P <0.05) and HDL-C increased after metformin treatment for 12 weeks (P <0.05). Conclusion After treatment with metformin for 12 weeks, FPG, 0.5hPG, 2hPG, HbA1c, TG, CH, HOMA-IR and Leptin in DM2 patients were significantly decreased and HDL-C increased.