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本文对比研究１１例Ｇｒａｖｅｓ病（ＧＤ）和９例非ＧＤ患者甲状腺静脉血（ＴＶＢ）和外周静脉血（ＰＶＢ）中甲状腺刺激抗体（ＴＳＡｂ）、甲状腺球蛋白抗体（ＴＧＡｂ）和甲状腺过氧化物酶抗体（ＴＰＯＡｂ）的活性和Ｔ３、Ｔ４浓度。结果显示：（１）抗体阳性的ＧＤ患者，其ＴＶＢ中ＴＳＡｂ、ＴＧＡｂ和ＴＰＯＡｂ水平均显著高于ＰＶＥ的，ＰＶＢ和ＴＶＢ的ＴＳＡｂ活性呈显著正相关，这提示甲状腺本身是甲状腺特异性抗体产生的主要部位；（２）ＧＤ组和非ＧＤ组ＴＶＢ和ＰＶＢ的血清Ｔ３、Ｔ４不形成浓度梯度；（３）ＴＳＡｂ、ＴＧＡｂ和ＴＰＯＡｂ活性及其在ＴＶＢ和ＰＶＢ之间的活性梯度，与ＴＶＢ和ＰＶＢ中Ｔ３、Ｔ４浓度均无相关关系。
This study compared the thyroid stimulating antibody (TSAb), thyroglobulin antibody (TGAb) and thyroid peroxidase (TGAb) in thyroid venous blood (TVB) and peripheral venous blood (PVB) in 11 patients with Graves disease (GD) Antibody (TPOAb) activity and T3, T4 concentration. The results showed that: (1) The levels of TSAb, TGAb and TPOAb in TVB were significantly higher in antibody-positive GD patients than in PVE, and there was a significant positive correlation between TSAb activity in PVB and TVB, suggesting that the thyroid itself is produced by thyroid-specific antibodies (2) Serum T3 and T4 of TVB and PVB did not form concentration gradient in GD group and non-GD group; (3) The activity of TSAb, TGAb and TPOAb and their activity gradient between TVB and PVB were similar to that of TVB and PVB T3, T4 concentrations were not related.