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促肾上腺皮质激素释放因子（ＣＲＦ）能神经元的胞体和轴突末梢广泛分布在中央杏仁核（ＡＣ）及其投射的重要升压区。本工作显示：（１）谷氨酸兴奋ＡＣ或将ＣＲＦ分别注入ＡＣ投射区：室旁核（ＮＰＶ）、外侧下丘脑／穹窿周围区（ＬＨ／ＰＦ）、蓝斑（ＬＣ）、臂旁核（ＮＰＢ）、中脑导水管周围灰质（ＰＡＧ）或延髓头端腹外侧区（ＲＶＬ）均引起升压反应；（２）ＡＣ的上述投射区内预先分别注入α－ＨｅｌｉｃａｌＣＲＦ［９－４１］（ＣＲＦ拮抗剂）均能阻断谷氨酸兴奋ＡＣ引起的升压反应。以上结果结合以往报道：ＬＨ／ＰＦ也有纤维投射至ＬＣ、ＮＰＢ和ＰＡＧ，后三者均可通过ＲＶＬ引起升压反应，表明ＡＣ发出的ＣＲＦ能投射纤维一方面可兴奋ＮＰＶ，另一方面则可间接（通过ＬＨ／ＰＦ）或直接作用于ＬＣ、ＮＰＢ和ＰＡＧ，进而激活ＲＶＬ－交感兴奋神经元，也可能直接兴奋ＲＶＬ而引起升压反应
The somatic and axonal terminals of corticotropin-releasing factor (CRF) -dependent neurons are widely distributed in the central amygdala (AC) and its important regions of elevated pressure. This work shows: (1) glutamate excitatory AC or CRF were injected into the AC projection area: paraventricular nucleus (NPV), lateral hypothalamic / vault (LH / PF), locus coeruleus (LC) (NPB), midbrain periaqueductal gray (PAG), or rostral ventrolateral medulla (RVL). (2) α-Helical CRF was injected into the above projection areas of AC [9-41] CRF antagonist) can block glutamate-induced AC induced vasorelaxation. The above results combined with previous reports: LH / PF also have fibers projected to the LC, NPB and PAG, the latter three can be caused by the RVL boost reaction, indicating that the ACF emitted CRF fibers can be excited on the one hand excited NPV, on the other hand can be Indirect (via LH / PF) or direct action on LC, NPB and PAG, which in turn activates RVL-sympathetic excitatory neurons, may also directly stimulate RVL and cause a vasopressor response