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目的:探讨氯胺酮、异丙酚复合利多卡因用于小儿手术麻醉效果。方法:76例择期行外科手术患儿按照随机数字表法均分为观察组和对照组,每组38例。观察组患儿采取氯胺酮、异丙酚复合利多卡因进行麻醉,对照组患儿采取静脉滴注氯胺酮麻醉。观察两组患儿麻醉前5 min、麻醉后5 min、麻醉后15 min、麻醉后30 min RR、HR、SBP、Sp O2变化,观察两组患儿不良反应发生率。结果:两组患者手术前后RR、HR、SBP、Sp O2无显著变化,与手术前比较,差异无统计学意义(P>0.05);观察患儿麻醉结束后氯胺酮使用总剂量为(118.16±22.53)mg,显著低于对照组的(150.26±26.77)mg,差异具有统计学意义(P<0.05);观察组患儿不良反应发生情况显著低于对照组,与对照组比较,差异具有统计学意义(P<0.05)。结论:氯胺酮、异丙酚复合利多卡因用于小儿手术麻醉临床疗效佳,对患儿生命体征无显著影响,而且不良反应发生率少,值得临床推广。
Objective: To investigate the anesthetic effects of ketamine and propofol combined with lidocaine for pediatric surgery. Methods: Totally 76 children undergoing elective surgery were divided into observation group and control group according to random number table method, with 38 cases in each group. Children in the observation group were anesthetized with ketamine and propofol plus lidocaine, while those in the control group were given ketamine anesthesia. The changes of RR, HR, SBP and Sp O2 in the two groups were observed 5 min before anesthesia, 5 min after anesthesia, 15 min after anesthesia and 30 min after anesthesia. The incidence of adverse reactions in both groups were observed. Results: There was no significant difference in RR, HR, SBP and Sp O2 between the two groups before operation (P> 0.05), and the total dose of ketamine was (118.16 ± 22.53 ) mg, significantly lower than that of the control group (150.26 ± 26.77) mg, the difference was statistically significant (P <0.05); adverse reactions in the observation group were significantly lower than the control group, compared with the control group, the difference was statistically significant Significance (P <0.05). Conclusions: Ketamine and propofol combined lidocaine are effective in pediatric anesthesia and have no significant effect on the vital signs of children. Moreover, the incidence of adverse reactions is small and worthy of clinical promotion.