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各种神经疾病和症状在月经期中都可加重,但以癫痫发作加重最突出。1885年,Gowers首先发现月经与癫痫的关系。多数研究者发现接近排卵期和行经期犯病率增高。实验室评价:月经期癫痫的原因在水代谢和内分泌变化方面曾进行大量研究。McQuarrie认为水代谢变化可激发潜在的月经期发作。有关激素影响月经期发作的研究很多。Buchanan等(1912)指出苯妥英,苯巴比妥和许多内生类固醇靠同一类代谢酶代谢和羟化,故继激素治疗之后,抗癫痫药的代谢有加强和减弱现象。Kutt等(1968)观察到1例病人在雌激素治疗后发生苯妥英中毒。Fernandez-Pol等(1975)发现雌激素治疗可使苯妥英的半衰期延长,他们推想这是由
A variety of neurological diseases and symptoms can be aggravated during menstruation, but the most prominent increase in seizures. In 1885, Gowers first discovered the relationship between menstruation and epilepsy. Most researchers found that the incidence of ovulation and menstrual morbidity increased. Laboratory evaluation: The causes of menstrual epilepsy A large number of studies have been conducted on water metabolism and endocrine changes. McQuarrie believes that changes in water metabolism can trigger a potential menstrual seizures. There are many studies on the effects of hormones on menstrual seizures. Buchanan et al. (1912) pointed out that phenytoin, phenobarbital and many endogenous steroids by the same type of metabolic enzymes metabolism and hydroxylation, so following hormone therapy, antiepileptic drugs have increased and weakened the metabolism. Kutt et al. (1968) observed that 1 patient developed phenytoin poisoning after estrogen therapy. Fernandez-Pol et al. (1975) found that estrogen therapy prolongs the half-life of phenytoin, which they hypothesized to be caused by