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目的探讨CK7、P63乳腺硬化性腺病与乳腺癌中的临床病理分析。方法选取该院2014年1月-2015年1月收治的60例乳腺癌及40例乳腺硬化性腺病患者的病理学标本为研究对象,对其进行免疫组化检测,分析CK7、P63的阳性表达情况。结果 CK7呈颗粒状表达于腺上皮的胞浆中,CK7在乳腺硬化性腺病的表达高于乳腺癌,差异有统计学意义(P<0.05)。P63主要表达于导管周围的肌上皮,P63在乳腺硬化性腺病的表达高于乳腺癌,差异有统计学意义(P<0.05)。结论 CK7、P63能够客观地显示出乳腺腺泡和导管的基本结构,在乳腺硬化性疾病的表达加强,恶性肿瘤较弱,可用于乳腺硬化性腺病与乳腺癌的鉴别诊断。
Objective To investigate the clinicopathological features of CK7 and P63 in patients with breast sclerosis and breast cancer. Methods The pathological specimens from 60 patients with breast cancer and 40 patients with sclerosing adenomyosis treated in our hospital from January 2014 to January 2015 were enrolled in this study. Immunohistochemistry was used to detect the positive expression of CK7 and P63 Happening. Results The expression of CK7 was grainy in the cytoplasm of glandular epithelium. The expression of CK7 in breast sclerosing adenosis was higher than that in breast cancer (P <0.05). P63 was mainly expressed in the myoepithelial duct around the duct. The expression of P63 in breast sclerosing adenosis was higher than that in breast cancer, the difference was statistically significant (P <0.05). Conclusions CK7 and P63 can objectively show the basic structure of mammary gland acini and duct. The expression of CK7 and P63 in breast sclerosis is strengthened and the malignant tumor is weak. It can be used in the differential diagnosis of breast sclerosing adenosis and breast cancer.