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目的：观察双氯芬酸钾栓(普他宁)治疗儿童感染性发热的疗效。方法纳入我院2013年5月至2014年5月100例因感染性发热入院就诊的儿童，随机分为两组。治疗组（50例）给予普他宁栓塞肛；对照组（50例）给予泰诺林口服。观察两组患儿用药后不同时间体温变化及不良反应，对两组患者治疗前后白介素-6水平及血清降钙素原水平进行对比，判定两种药物的临床疗效。结果两组患者治疗后，实验组有效率48（96%）与对照组42（84%）对比差异显著，P=0.046<0.05,具有统计学意义；实验组患者治疗后总不良反应率（χ2=6.06， P=0.01<0.05）对比对照组具有显著差异，具有统计学意义；实验组血清降钙素原（Z=6.74，P=0.012）对比对照组差异显著，具有统计学意义。结论普他宁治疗儿童发热具有更显著的临床效果，值得大力推广。“,”Objective Experiments to explore the treatment of children diclofenac potassium suppository fever effect.Methords Included in our hospital from May 2013 to May 2014 100 cases of children hospitalized for treatment of fever, were randomly divided into two groups. Treatment group of 50 patients, using the method of treatment Pu Ning his treatment; the control group of 50 patients, the use of treatment methods for treatment Tylenol. The results of the blood tests and interleukin-6 levels were compared before and after treatment to determine the clinical efficacy of both drugs.Result After treatment, the experimental group was 48 (96%) and the control group 42 (84%) comparing the difference was significant, P = 0.046 <0.05, statistical y significant; the total rate of adverse events (χ2= 6.06, P = 0.01 <0.01) compared to control there were significant differences between groups, with statistical significance; experimental group serum procalcitonin (Z= 6.74, P = 0.012) compared to control group significantly different, with statistical significance .Conclusion Diclofenac suppository treatment of children with fever have more significant clinical effect, it is worth promoting.