目的探讨新生儿血清TORCH病原Ig G及Ig M抗体的分布特点,为新生儿中TORCH相关疾病血清学筛查提供依据。方法收集2010年10月—2013年9月门诊就诊患儿12 472人次的血清TORCH病原Ig G与Ig M抗体检测资料,分成新生儿组和非新生儿组,比较两组血清TORCH病原Ig G及Ig M抗体阳性率差异。结果新生儿组TOX-Ig G、HSVⅡ-Ig G、HSVⅠ-Ig G和CMV-Ig G抗体阳性率高于非新生儿组(P均<0.05),但RUV-Ig G在两组间差异无统计学意义(P>0.05),而HSVⅡ-Ig M、HSVⅠ-Ig M、CMV-Ig M和RUV-Ig M阳性率则明显低于非新生儿组(P均<0.05);但TOX-Ig M阳性率两组间差异无统计学意义(P>0.05)。结论新生儿HSVⅡ-Ig G、HSVⅠ-Ig G、CMV-Ig G和TOX-Ig G抗体检测阳性率较高,而代表出生后自身获得性感染出现的HSVⅡ-Ig M、HSVⅠ-Ig M和CMV-Ig M抗体却较低,提示该类Ig G抗体多数为母源性抗体的可能较大。 Objective To explore the distribution characteristics of Ig G and Ig M antibodies in neonatal TORCH pathogens and provide the basis for serological screening of TORCH related diseases in neonates. Methods The serum TORCH pathogen Ig G and Ig M antibody test data of 12 472 outpatients from October 2010 to September 2013 were collected and divided into neonatal group and non-neonatal group. The serum TORCH pathogen Ig G, Ig M antibody positive rate difference. Results The positive rates of TOX-Ig G, HSVⅡ-Ig G, HSVⅠ-Ig G and CMV-Ig G in neonates were higher than those in non-neonates (all P <0.05). However, there was no significant difference in RUV-Ig G between the two groups The positive rates of HSVⅡ-Ig M, HSVⅠ-Ig M, CMV-Ig M and RUV-Ig M were significantly lower than those of non-neonates (all P <0.05) M positive rate was no significant difference between the two groups (P> 0.05). Conclusions The detection rate of HSVⅡ-Ig G, HSVⅠ-Ig G, CMV-Ig G and TOX-Ig G in neonates is higher than that in HSVⅡ-Ig M, HSVⅠ-Ig M and CMV -Ig M antibody is lower, suggesting that most of these Ig G antibodies may be more maternal antibodies.