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中药角蒿(Incarvillea sinensis)用于治疗风湿病和缓解疼痛,曾报道从角蒿中分离出的一种单萜生物碱incarvillateine(1)对甲醛致痛模型小鼠,具有显著抗伤害感受作用。本次研究了(1)的结构与其抗伤害感受活性之间的关系。 材料与方法:试验品用化合物1及其最小结构单位E-阿魏酸(2)和角蒿灵(incarvilline,3),以及单萜生物碱衍生物
Incarvillea sinensis is used to treat rheumatism and relieve pain. It has been reported that a monoterpene alkaloid incarvillateine (1) isolated from Artemisia halodendron has a significant antinociception effect on formaldehyde-induced model mice. This study investigated the relationship between the structure of (1) and its antinociceptive activity. Materials and Methods: Compound 1 for the test product and its minimum structural units E-ferulic acid (2) and incarvilline (3), and monoterpene alkaloid derivatives