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目的:更进一步对乙型肝炎疫苗结合乙型肝炎免疫球蛋白阻断HBV的母婴传播的免疫效果进行分析研究。方法:选取2011-2015五年期间在不同医院的HBsAg阳性孕妇所生婴儿共115例,婴儿出生时均接种1剂次10ug乙型肝炎疫苗,并给予1剂次乙型肝炎免疫球蛋白,在1、6月龄时均按程序接种1剂次10ug乙肝疫苗。对这些HBsAg阳性孕妇所生儿童在接种后1岁半到两岁左右进行乙肝两对半检测,并记录检测结果。对其中检测结果全阴者按乙肝疫苗免疫程序重新补种三剂次。结果:乙型肝炎免疫球蛋白和乙型肝炎疫苗结合使用其阻断效果明显,但是不能达到100%阻断,有很少一部分人未能达到保护作用。结论:要想有效的阻断HBV的母婴传播,需要乙型肝炎免疫球蛋白和乙型肝炎疫苗结合使用才能达到最佳效果。且原有的免疫方法不够完善,应按照新版国家免疫规划程序来进行改进。
OBJECTIVE: To further analyze the immune effect of hepatitis B vaccine combined with hepatitis B immunoglobulin in blocking mother-to-child transmission of HBV. Methods: A total of 115 infants born to HBsAg-positive pregnant women in different hospitals during the five-year period from 2011 to 2015 were selected. The infants were vaccinated with one dose of Hepatitis B vaccine and one dose of Hepatitis B immunoglobulin at birth. 1, 6 months of age were vaccinated according to the procedure 1 dose of 10ug hepatitis B vaccine. Children born to these HBsAg-positive pregnant women were tested for hepatitis B by two pairs and half pairs after 1 and a half to two years of age after vaccination, and the test results were recorded. The test results of all those who are negative by hepatitis B vaccine re-vaccination three times. Results: Hepatitis B immunoglobulin and hepatitis B vaccine combined with its blocking effect is obvious, but can not achieve 100% block, a small number of people failed to achieve the protective effect. Conclusion: In order to effectively block the mother-to-child transmission of HBV, the combination of hepatitis B immunoglobulin and hepatitis B vaccine is needed to achieve the best effect. And the original immune method is not perfect, should be in accordance with the new version of the national immunization program to be improved.