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作者用市售的混合酯在热甲醇中溶解后,随温度的下降,依次析出三、二、单硬脂酸甘油酯及三、二、单硬脂酸山梨醇酯,而游离甘油和山梨醇及它们的油酸酯存在于母液中。由此,制得了较好的单硬脂酸甘油酯。 1、单硬脂酸甘油酯(MGS)对口服制剂的崩解: 用MGS配制的丸剂,在崩解器中,用pH1.2酸性试液,几乎看不到变化,室温试验8小时仅看到很少的表面裂痕。而在pH6.5、7.5、8.2的试液中,制剂吸水、膨胀、软化、开始剥落,50分钟后溶液变浑浊,随着时间的增加,试液的浊度也增加,制剂的厚度则减
The authors use commercially available mixed esters dissolved in hot methanol, followed by the precipitation of three, two, glycerol monostearate and three, two, sorbitol monostearate ester, while the free glycerol and sorbitol And their oleates are present in the mother liquor. As a result, a good glycerol monostearate was obtained. 1, disintegration of oral formulations of glycerol monostearate (MGS): pills formulated with MGS in the disintegrator, with pH1.2 acidic test solution, almost no change in room temperature test 8 hours only to see To few surface cracks. In the pH 6.5, 7.5, 8.2 test solution, the preparation absorbs water, expands, softens and begins to peel off. After 50 minutes, the solution becomes turbid. With the increase of time, the turbidity of the test solution also increases, and the thickness of the preparation decreases