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目的 动态研究鼻咽癌放疗对视诱发电位的改变。方法 对 6 3例鼻咽癌患者于放疗前、放疗终、放疗后的半年和 1,2 ,3年分别做一次视诱发电位 (VEP)检测 ,并进行自身对照分析。结果男组放疗后 1年的VEP潜伏期比放疗前、放疗终显著延长 ,VEP振幅显著下降 ;放疗后 2年的VEP潜伏期比放疗前显著延长 ,而放疗终及放疗后半年、3年的潜伏期与放疗前比较 ,差异无显著性。女组放疗后 2年的VEP潜伏期比放疗前显著延长 ,放疗后 3年的VEP潜伏期比放疗前、放疗终及放疗后半年、1年显著延长 ;而放疗后 0～ 3年的VEP振幅与放疗前比较 ,差异无显著性。结论 放射线治疗鼻咽癌会对患者的视觉神经系统造成一定的损害 ,所出现的延迟性损伤存在着性别差异。
Objective To study the changes of visual evoked potentials in nasopharyngeal carcinoma treated by radiotherapy. Methods Sixty-three patients with nasopharyngeal carcinoma before radiotherapy, the end of radiotherapy, six months after radiotherapy and one, two, three years were made a visual evoked potential (VEP) test, and self-control analysis. Results The VEP latency at 1 year after radiotherapy in men was significantly longer than that before radiotherapy, and the VEP amplitude was significantly decreased. The VEP latency at 2 years after radiotherapy was significantly longer than that before radiotherapy. However, at the end of radiotherapy and half a year after radiotherapy, the 3-year latency and Before radiotherapy, the difference was not significant. The VEP latency of women in the two years after radiotherapy was significantly longer than that before radiotherapy. The latency of VEP after 3 years of radiotherapy was significantly longer than that before radiotherapy, at the end of radiotherapy and half a year after radiotherapy. The amplitude of VEP at 0 to 3 years after radiotherapy was significantly higher than that of radiotherapy Before comparison, the difference was not significant. Conclusion Radiotherapy of nasopharyngeal carcinoma will cause some damage to the visual nervous system of patients, there is a gender difference in delayed injury.