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观察20例新生一周豚鼠腹腔给予胆红素100μg／g（T1组）、200ug／g（T2组）造胆红素脑病模型前、4hr后（Ta组）、8hr后（Tb组）闪光视觉诱发电位（F－VEP），及其与胆红素神经毒性参数相关性。结果显示：不同模型组F－VEP变化表现有显著差异，胆红素脑病模型豚鼠F－VEP变化与血清胆红素，脑组织胆红素无显著相关（P＞0．05），与脑组织能量代谢水平相关有显著性（P＜0．05），与神经病理及神经行为变化相关有非常显著意义（P＜0．01）。表明：F－VEP可灵敏地反映胆红素脑病模型豚鼠中枢神经功能状态的变化，检测胆红素神经毒性较可靠。
The bilirubin 100 μg / g (T1 group), 200 μg / g (T2 group) bilirubin encephalopathy model were observed intraperitoneally in 20 neonatal guinea pigs in one week, 4 hours later (Ta group) and 8 hours later (Tb group) Potential (F-VEP), and its correlation with bilirubin neurotoxicity parameters. The results showed that the changes of F-VEP in different model groups were significantly different. The change of F-VEP in bilirubin encephalopathy model was not significantly correlated with serum bilirubin and brain tissue bilirubin (P> 0.05) There was a significant correlation between energy metabolism level (P <0.05) and neuropathological and neurobehavioral changes (P <0.01). The results showed that F-VEP could sensitively reflect the functional status of central nervous system in guinea pigs with bilirubin encephalopathy, and the neurotoxicity of bilirubin was more reliable.