论文部分内容阅读
目的探讨胃肠道间质瘤(GIST)的临床特点与诊治体会。方法对51例经手术治疗的胃肠道间质瘤患者的临床资料进行回顾性分析,并应用3种抗体(CD117、CD34、SMA)通过免疫组化方法进行分析研究。结果 GIST主要发生于胃及小肠,在所有患者中CD117均呈阳性表达,胞质弥漫强阳性染色;CD34阳性表达率为86.3%(44/51);SMA阳性表达率为41.2%(21/51)。结论 GIST的临床表现和组织学检查无特异性,CD117和CD34标记阳性是确诊GIST最有价值的诊断依据,手术切除是其主要的治疗手段。
Objective To investigate the clinical features, diagnosis and treatment of gastrointestinal stromal tumors (GIST). Methods The clinical data of 51 patients with gastrointestinal stromal tumors treated by surgery were retrospectively analyzed and analyzed by immunohistochemistry using three kinds of antibodies (CD117, CD34, SMA). Results GIST mainly occurred in the stomach and small intestine. CD117 expression was positive in all patients, and the cytoplasm was strongly diffusely stained. The positive rate of CD34 was 86.3% (44/51) and the positive rate of SMA was 41.2% (21/51 ). Conclusion The clinical manifestations and histological examination of GIST are nonspecific. The positive staining of CD117 and CD34 is the most valuable diagnostic basis for the diagnosis of GIST. Surgical resection is the main treatment.