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目的观察妥洛特罗贴辅助治疗小儿喘息性疾病的疗效及安全性。方法以2012年1～8月在东莞市人民医院儿科接受治疗的小儿喘息性疾病患儿92例为研究对象,进行随机分组。两组均给予常规综合治疗,对照组加用沙丁胺醇联合雾化吸入;治疗组加用妥洛特罗贴。观察两组患儿治疗前后血IgE值、外周血EOS(嗜酸性粒细胞)计数的变化,并比较两组症状持续时间、治愈天数及不良反应等指标的差异。结果与治疗前相比较,两组患儿血IgE水平和外周血EOS水平均有一定程度的改善,其中治疗组改善程度明显较好,差异有统计学意义(P<0.05)。两组患儿临床疗效、咳嗽、哮鸣音消失时间、治愈天数等比较,差异无统计学意义(P>0.05)。治疗组不良反应明显低于对照组。结论采用妥洛特罗贴辅助治疗小儿喘息性疾病,其临床疗效与沙丁胺醇相当且副作用少,同时可有效降低患儿血IgE、外周血EOS水平,改善患儿免疫状态,与激素联用具有良好的协同抗炎作用,对治疗小儿喘息性疾病安全有效。
Objective To observe the efficacy and safety of tulobuterol in adjuvant treatment of infantile wheezing diseases. Methods From January to August 2012 in Dongguan City People’s Hospital pediatric treatment of children with asthma in 92 cases of children as the research object, were randomly divided into groups. Both groups were given conventional comprehensive treatment, the control group plus salbutamol combined with inhalation; the treatment group plus tulobuterol stickers. The changes of blood IgE and EOS count in both groups were observed before and after treatment. The differences in the duration of symptoms, days of cure and adverse reactions between the two groups were compared. Results Compared with those before treatment, blood IgE level and EOS level in peripheral blood in both groups improved to a certain extent. The improvement in treatment group was significantly better, with significant difference (P <0.05). There was no significant difference between the two groups in clinical curative effect, cough, disappearance of wheeze, days of cure, etc. (P> 0.05). Adverse reactions in the treatment group were significantly lower than those in the control group. Conclusion The application of tulobuterol in adjuvant treatment of children with wheezing diseases, the clinical efficacy of salbutamol with side effects and less, at the same time can effectively reduce the blood IgE in children, peripheral blood EOS levels, improve children with immune status, with hormone combination has good Synergistic anti-inflammatory effect, safe and effective treatment of children with wheezing diseases.