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目的 :评价外照射加腔内后装治疗鼻咽癌的疗效及其并发症。方法 :外照射加腔内治疗 73例 T1～ 2 期鼻咽癌 (腔内组 ) ,选择同期单纯外照射的 70例 T1～ 2 期鼻咽癌作对照 (外照组 )。腔内组外照射 6 0～ 70 Gy后行腔内放疗 ,剂量为 8～18Gy。外照组单纯外照射剂量 6 8～ 82 Gy。结果 :腔内组和外照组的 1、 3、 5年生存率分别为 10 0 %、86 .3%、71.3%和 98.6 %、82 .9%、 6 4.0 % ,经 L ong- rank法检验两者之间差异无统计学意义 (P >0 .0 5 ) ;3、 5年局部控制率分别为 98.6 %、 91.6 %和 88.4%、 82 .5 % ,其中 3年局控率两者差异呈显著性 (P <0 .0 5 ) ,5年局控率差异无显著性 (P >0 .0 5 )。并发症 :张口困难 :腔内组为 4例 (占 5 .5 % ) ,外照组 11例 (占 15 .7% ) ,两者差异呈显著性 (P <0 .0 5 ) ;外照组出现 2例后组颅神经受损。结论 :提示外照射加腔内治疗鼻咽癌 ,可提高近期局部控制率 ,减少后遗症发生 ,未见提高长期生存率和长期局部控制率。
Objective: To evaluate the efficacy and complications of external beam radiation and intracavitary after-treatment in the treatment of nasopharyngeal carcinoma. Methods: Totally 73 cases of T1 ~ 2 nasopharyngeal carcinoma (endoluminal group) treated by external irradiation and endovascular treatment were selected as control group. Endoluminescence group after 60 ~ 70 Gy after radiotherapy, the dose of 8 ~ 18Gy. The external radiation dose alone was 68 ~ 82 Gy. Results: The 1, 3, 5-year survival rates of the endometriosis group and the control group were 100%, 86.3%, 71.3% and 98.6%, 82.9% and 6 4.0% There was no significant difference between the two groups (P> 0.05). The local control rates at 3 and 5 years were 98.6%, 91.6% and 88.4%, 82.5% respectively, of which the three-year local control rate The difference was significant (P <0.05). There was no significant difference in the 5-year local control rate (P> 0.05). Complications: Difficult mouth: 4 cases (5. 5%) in the endovascular group and 11 cases (15.7%) in the external group, the difference was significant (P <0. 05) Group 2 cases occurred after cranial nerve injury. Conclusion: It is suggested that external irradiation plus endovascular treatment of nasopharyngeal carcinoma can improve the recent local control rate, reduce the occurrence of sequelae, and improve long-term survival rate and long-term local control rate.