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目的研究子宫富细胞平滑肌瘤的临床及病理特征。方法分析了47例子宫富细胞平滑肌瘤的临床及病理特征,并对其中35例进行追踪随访。结果本病临床症状主要包括月经改变、贫血、疼痛、不孕等。术前诊断均为子宫肌瘤。术中所见符合子宫良性肿瘤特征,未见子宫外扩散或腹水。大体标本特征与普通的子宫肌瘤相似。病理组织学检查见部分区域肿瘤细胞丰富,排列紧密,但肿瘤细胞大小、形态仍较一致,核异形性少,每10个高倍视野下核分裂相少于5个。治疗方法分别为行肌瘤剔出术、次全子宫或全子宫切除术。术后随访35例,均存活至今。有5例术后肌瘤复发,其中4例为肌瘤剔出术后局部复发,1例为次全子宫切除术后宫颈残端复发。结论子宫富细胞平滑肌瘤是一种良性肿瘤,术后不必补充化疗或放疗,预后良好。
Objective To study the clinical and pathological features of uterine leucoma leiomyoma. Methods The clinical and pathological features of 47 cases of uterine leucoma leiomyoma were analyzed and 35 cases were followed up. Results The clinical symptoms include menstrual changes, anemia, pain, infertility and so on. Preoperative diagnosis of uterine fibroids. See intraoperative findings consistent with benign tumor characteristics of the uterus, no extrauterine proliferation or ascites. The general characteristics of specimens and ordinary uterine fibroids similar. Histopathological examination showed that the tumor cells in some areas were abundant and closely arranged. However, the size and shape of the tumor cells were still consistent, with less nuclear atypia. There were fewer than 5 mitotic cells per 10 high power fields. Treatment were line myoma excision, subtotal hysterectomy or hysterectomy. All patients were followed up 35 cases, all survived to this day. There were 5 cases of fibroids recurrence, of which 4 cases of local recurrence after myomectomy, and 1 case of recurrence of cervical stump after subtotal hysterectomy. Conclusions Uterine leucoma leiomyoma is a benign tumor without postoperative chemotherapy or radiotherapy and has a good prognosis.