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目的:探讨Dixon手术直肠下端切缘p53基因突变情况及其与肿瘤预后的关系.方法:分析1990年以来Dixon直肠癌根治手术病人术后三年以内死亡和生存五年以上两组病例的临床情况,采用免疫组化的方法,检测两组不同生存期病人的直肠癌下段切缘p53基因突变率.结果:两组病例在肿瘤位于直肠的位置和病理的淋巴转移率有显著差异.在两组直肠下端病理均未见癌细胞的情况下,三年组p53突变检测分析3/19阳性,而五年组为2/24阳性.无显著性差异.结论:病理检查肿瘤切缘为正常细胞的部位,确实存在分子水平的、肿瘤相关异常基因细胞,表现为散在性点状、巢状分布.这应非一种孤立的、偶然的表现.
Objective: To investigate the relationship between the mutation of p53 gene in the lower rectum of Dixon’s surgery and its prognosis.Methods: To analyze the clinical data of patients who underwent Dixon’s rectal cancer radical surgery three years after their death and survival for more than five years , And the immunohistochemical method was used to detect the mutation rate of p53 gene in the lower rectal cancer margin of two groups of patients with different survival.Results: There was a significant difference between the two groups in the location of the rectum and the pathological lymph node metastasis in both groups In the three-year group, p53 mutation was detected 3/19 positive in the three-year group and 2/24 was positive in the five-year group, with no significant difference.Conclusion: The pathological section of the tumor was normal cell There is indeed a molecular level of tumor-related abnormal gene cells, showing scattered spot-like, nested distribution, which should not be an isolated, incidental manifestation.