The existing research of process capability indices of multiple quality characteristics mainly focuses on nonconforming of process output, the concept development of univariate process capability indices, quality loss function and various comprehensive evaluation methods. The multivariate complexity increases the computation difficulty of multivariate process capability indices(MPCI), which makes them hard to be used in practice. In this paper, a new PCA-based MPCI approach is proposed to assess the production capability of the processes that involve multiple product quality characteristics. This approach first transforms the original quality variables into standardized normal variables. MPCI measures are then provided based on the Taam index. Moreover, the statistical properties of these MPCIs, such as confidence intervals and lower confidence bound, are given to let the practitioners understand the capability indices as random variables instead of deterministic variables. A real manufacturing data set and a synthetic data set are used to demonstrate the effectiveness of the proposed method. An implementation procedure is also provided for quality engineers to apply our MPCI approach in their manufacturing processes. The case studies demonstrate the effectiveness and feasibility of this new kind of MPCI, which is easier to be used in production practice. The proposed research provides a novel approach of MPCI calculation. The existing research of process capability indices of multiple quality characteristics primarily focused on nonconforming of process output, the concept development of univariate process capability indices, quality loss function and various comprehensive evaluation methods. The multivariate complexity increases the computational difficulty of multivariate process capability indices ( MPCI), which makes them hard to be used in practice. In this paper, a new PCA-based MPCI approach is proposed to assess the production capability of the processes that involve multiple product quality characteristics. This approach first transforms the original quality variables into standardized normal variables. MPCI measures are then provided based on the Taam index. Moreover, the statistical properties of these MPCIs, such as confidence intervals and lower confidence bound, are given to let the practitioners understand the capability indices as random variables instead of deterministic variables A real manu facturing data set and a synthetic data set are used to demonstrate the effectiveness of the proposed method. an implementation procedure is also provided for quality engineers to apply our MPCI approach in their manufacturing processes. of MPCI, which is easier to be used in production practice. The proposed research provides a novel approach of MPCI calculation.