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Poly(3, 4-ethylenedioxythiophene)(PEDOT), together with its dopes, such as poly(styrene sulfonate)(PSS), has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide(ITO)-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy(EIS) and increases charge delivery capacity relative to the gelatin layer and bare ITOcoated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITOcoated glass enhances pheochromocytoma(PC 12) cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.
Poly this (3, 4-ethylenedioxythiophene) (PEDOT), together with its dopes, such as poly (styrene sulfonate) (PSS), has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin PEDOT / PSS / gelatin layer on ITO-coated glass greatly reduced electrochemical impedance spectroscopy (EIS) and increases charge delivery capacity relative to the gelatin layer and bare PEDOT / PSS / gelatin layer on ITOcoated glass enhances pheochromocytoma (PC 12) cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into PEDOT / PSS polymers through electrochemical polymerization and the PEDOT / PSS / gelatin layer on ITO-coated glass possesses high electrochemical and biological activit ies.