论文部分内容阅读
自1996年高效抗反转录病毒治疗(HAART)应用于临床以来,AIDS的发病率和病死率明显下降。但HAART的不良反应同时也引起普遍关注。抗反转录病毒(ARV)药物中的蛋白酶抑制剂、核苷(酸)类反转录酶抑制剂,以及两者联合应用引起的脂肪分布异常、代谢综合征是较常见的远期不良反应。在接受HAART的AIDS患者中,其发病率可达50%(11%∽83%)。脂肪组织本身是重要的内分泌器官,具有代谢调节功
Since 1996, when high-potency antiretroviral therapy (HAART) has been applied clinically, the incidence and mortality of AIDS have dropped significantly. However, HAART adverse reactions also caused widespread concern. Anti-retroviral (ARV) drugs in the protease inhibitors, nucleoside (acid) reverse transcriptase inhibitors, and the combined use of both fat-induced abnormalities, metabolic syndrome is the more common long-term adverse reactions . In AIDS patients receiving HAART, the incidence of up to 50% (11% ∽ 83%). Adipose tissue itself is an important endocrine organ, with metabolic regulation work