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目前认为,阿片依赖者在戒断期间或使用纳洛酮催瘾时,蓝斑去甲肾上腺素能神经元放电显著增加[1]。推测戒断症状与中枢去甲肾上腺素的释放密切相关[1,2]。故海洛因依赖大鼠纳洛酮戒断后将引起心血管活动的改变,但对海洛因依赖大鼠纳洛酮戒断后血压的变化,文献报道并不一致。因此
It is currently believed that blue-spot noradrenergic neuronal discharges are significantly increased during opiate withdrawal or withdrawal from naloxone [1]. Speculated withdrawal symptoms and central norepinephrine release are closely related [1,2]. Therefore, heroin dependence rats naloxone withdrawal will cause changes in cardiovascular activity, but heroin addicted to rats after naloxone withdrawal of blood pressure changes reported in the literature is not consistent. therefore