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作者先前证实,与无幽门螺旋菌(HP)感染的健康志愿者相比较,静脉注射胃泌素释放肽(GRP)引起胃泌素介导的酸分泌在有HP感染的DU患者增长6倍,在有HP感染的健康志愿者达3倍。根治HP使DU病人的酸分泌下降66％。本研究用以确定根治HP对健康志愿者胃泌素介导的酸分泌所起的作用。方法:11名(7名男性)有HP感染的健康志愿者在45min基础阶段后以40 pmol/kg·h速度输注GRP。在全过程每15min抽血测胃泌素,抽胃液查排酸量。在3周抗HP三联疗法结束后1月重复以上检查。结果:治疗前,输注GRP时胃泌素中位值为238ng/L(范围50～420),根治HP后降至45ng/L(范围25～293)(P<0.008)。治疗前输注GRP时排酸量中位值
The authors previously demonstrated that intravenous gastrin-releasing peptide (GRP) causes gastrin-mediated acid secretion to increase 6-fold in patients with HP-infected DU compared to healthy volunteers without Helicobacter pylori (HP) infection, Up to 3 times more healthy volunteers with HP infection. Radical HP reduced the acid secretion of DU patients by 66%. This study was designed to determine the effect of radical HP on gastrin-mediated acid secretion in healthy volunteers. METHODS: Eleven (7 men) healthy volunteers with HP infection were infused with GRP at a rate of 40 pmol / kg · h after a 45-min basal phase. In the whole process every 15min blood gas testing gastrin, pumping gastric juice check acid. In 3 weeks after anti-HP triple therapy in January repeat the above examination. Results: Before treatment, the mean value of gastrin during GRP infusion was 238 ng / L (range 50-420). After treatment of HP, the level of gastrin decreased to 45 ng / L (range 25-293) (P <0.008). Median acid output before GRP infusion