1前言由英国捷利康公司开发的粉唑醇是甾醇脱甲基化抑制剂,具有内吸、保护和铲除作用,是植物叶片和穗的广谱杀菌剂,对谷物白粉病、云形病、叶斑病和锈病有效。该产品于1983年商品化,国内有少数厂家生产,但至今无详细的合成报道。粉唑醇的合成途径很多,归纳起来主要有两类方法。方法一,经二苯基环氧乙烷与1,2,4-三唑钠盐 1 Introduction fluconazole developed by the British Zellikon alcohol is a sterol demethylation inhibitor, with internal absorption, protection and eradication, is a broad-spectrum fungicide plant leaves and spikes, powdery mildew, cloud disease, Leaf spot and rust are effective. The product was commercialized in 1983, a small number of domestic manufacturers, but so far no detailed synthesis report. There are many ways to synthesize fluconazole, and there are two main methods. Method one, diphenyl oxide and 1,2,4-triazole sodium salt