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目的探讨骨化三醇治疗小儿佝偻病的效果。方法选取150例1～3岁的佝偻病患儿,随机分为3组,每组50例,治疗1组每日口服骨化三醇1粒(0.25μg),治疗2组每日2粒(0.50μg),对照组则每日给予普通维生素D2 2 000 IU。治疗1个月后比较各组患儿治疗前后临床表现(夜惊、多汗、烦闹、枕秃等)改善情况,以及身高、血清钙、骨碱性磷酸酶(BALP)、血清25羟维生素D3、骨密度的变化情况。采用SPSS 13.0软件进行统计学分析。结果各组患儿临床表现(夜惊、多汗、烦闹、枕秃)均有改善;各组患儿身高、体质量均有增长,组间比较均无统计学差异;三组间血清钙比较无统计学差异;治疗后BALP下降、血清25羟维生素D3水平及骨密度升高,与治疗前比较差异均有统计学意义(Pa<0.01),治疗2组最明显。结论骨化三醇治疗儿童佝偻病疗效显著,0.50μg.d-1对北方地区儿童佝偻病能够起到治疗作用。
Objective To investigate the effect of calcitriol on children with rickets. Methods A total of 150 children aged 1 ~ 3 years old were randomly divided into 3 groups (50 in each group). One group received daily oral administration of calcitriol (0.25 μg), and the other two groups received 2 daily doses of 0.50 μg), while the control group was given ordinary vitamin D2 2 000 IU daily. One month after the treatment, the improvement of clinical manifestations (night scared, hyperhidrosis, bothering, pillow-baldness, etc.) before and after treatment in each group were compared, and the changes of height, serum calcium, bone alkaline phosphatase (BALP), serum 25 hydroxyvitamin D3, changes in bone mineral density. SPSS 13.0 software was used for statistical analysis. Results The clinical manifestations (nocturnal fright, hyperhidrosis, annoyance, pillow-baldness) in each group were improved. The height and weight of the children in each group increased. There was no significant difference between the two groups. Serum calcium There was no significant difference between the two groups (P <0.01). After treatment, the level of BALP decreased, serum 25-hydroxyvitamin D3 and bone mineral density increased, with statistical significance (P <0.01). Conclusion calcitriol treatment of rickets in children with significant effect, 0.50μg.d-1 of rickets in children in the northern region can play a therapeutic role.