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爪蟾卵母细胞经注射鲫鱼（Ｃａｒａｓｓｉｕｓｃａｒａｓｓｉｕｓ）视网膜总ＲＮＡ后，可表达大量电压依赖性钾离子通道。在此基础上，我们进一步发现，一个特定序列的寡核着酸能专一地抑止该通道的表达。由于我们设计与合成的该片段与果蝇、小鼠中已克隆的钾通道中编码Ｎ端的一个多肽的ｍＲＮＡ完全互补，因此推测：鲫鱼视网膜中的Ｋ＋通道基因这个区域与其它物种的Ｋ＋通道有高度同源性，这为克隆该基因和研究它的功能提供了重要资料。
Xenopus oocytes can express a large number of voltage-dependent potassium channels after injection of total RNA in the retina of Carassius carassius. On this basis, we further found that a specific sequence of oligonucleotide acid can specifically inhibit the expression of the channel. Since the fragment we designed and synthesized is completely complementary to the mRNA of a polypeptide encoding the N-terminus of the cloned potassium channel in Drosophila and mouse, it is presumed that the K + channel gene in the carp retina and the K + channel of other species are High homology, which provides important information for cloning the gene and studying its function.