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目的探讨老年高血压患者血清尿酸水平与颈动脉粥样硬化的相关性。方法选取辽宁省人民医院2013年12月至2015年3月收治的93例老年高血压患者为研究对象,根据彩超颈动脉内膜中层厚度(IMT)测定结果进行分组,颈动脉粥样硬化患者51例为A组,颈动脉正常患者42例为B组。两组患者分别进行总胆固醇、体重指数、收缩压、舒张压、尿酸、肌酐等指标的比较,观察其与颈动脉IMT的相关性。结果 A组患者收缩压、总胆固醇、尿酸水平均明显高于B组,差异均有统计学意义(均P<0.05)。以患者体重指数、收缩压、舒张压、总胆固醇、肌酐、尿酸等作为自变量,颈动脉IMT为应变量,结果显示,颈动脉IMT与尿酸呈正相关性(r=0.423,P<0.05)。结论血清尿酸水平是老年高血压患者动脉粥样硬化形成的独立危险因素,因此,临床对于高血压合并高尿酸血症患者需要加以重视,及时控制病情发展,对降低心脑血管疾病发生具有积极意义。
Objective To investigate the relationship between serum uric acid level and carotid atherosclerosis in elderly patients with hypertension. Methods Ninety-three elderly hypertensive patients admitted to Liaoning Provincial People’s Hospital from December 2013 to March 2015 were selected and divided into groups according to the results of carotid artery intima-media thickness (IMT) measurement. Patients with carotid atherosclerosis 51 Cases of A group, 42 patients with normal carotid artery for the B group. Two groups of patients were compared total cholesterol, body mass index, systolic blood pressure, diastolic blood pressure, uric acid, creatinine and other indicators were compared with the carotid IMT observed. Results The systolic blood pressure, total cholesterol and uric acid in group A were significantly higher than those in group B (all P <0.05). With body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, creatinine and uric acid as independent variables and carotid IMT as dependent variables, carotid IMT was positively correlated with uric acid (r = 0.423, P <0.05). Conclusions Serum uric acid level is an independent risk factor for atherosclerosis in elderly patients with hypertension. Therefore, it is necessary to pay more attention to patients with hypertension complicated with hyperuricemia and to control the progression of the disease in time, which has a positive effect on reducing the occurrence of cardiovascular and cerebrovascular diseases .