青霉素G钾的精制及其质量对比

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青霉素G钾盐仍然是目前青霉素盐类使用较多的一个产品。但青霉素在贮存期中易于变质,超过效期即作为废品处理,就实际情况,青霉素超过效期,其生物活性并不是全部丧失,设若能通过精制除去失效部份,回收有效部份,这不仅变无用为有用,而且为伤病员提供更多的青霉素G钾,基于这种设想,我厂开始了过期青霉素G钾的精制工作,经过几年来工作中的实践,我们获得了预期目的。几年来,我们精制了过期结块变色,混入异物系的青霉素G钾达六百公斤以上,并将所得精制品分装成注射用成品,经过临床单位使用后,证实200余病例注射这种青霉素G钾时,效果很好,病员疼痛减轻,但由于工作任务关系,我们未作进一步分析鉴定,现将原精制工艺过程及其质量对比情况提供商确。 Penicillin G potassium salt is still a penicillin salt more use of a product. However, penicillin is susceptible to deterioration during storage and expires as a waste product. In actual conditions, the biological activity of penicillin is not completely lost. If the invalid part is recovered by purification and the effective part is recovered, this not only changes Useless for useful, but also for the wounded and sick to provide more penicillin G potassium, based on this idea, I began plant out of penicillin G potassium refining work, after several years of work in practice, we obtained the desired goal. Over the past few years, we refined the expired caking discoloration, mixed with foreign lines of penicillin G potassium more than 600 kilograms, and the resulting refined products divided into injection products, after clinical units, confirmed that more than 200 cases of injection of this penicillin G potassium, the effect is good, the patient’s pain relief, but because of the task, we did not make further analysis of the identification, the original refining process and quality comparison is indeed provided.
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