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目的探讨针对耐药幽门螺杆菌(H.pylori)的再根除方案。方法 25例已经过2个疗程根除治疗的H.pylori感染患者,尿素呼气试验阳性。随机纳入不同的治疗方案组:A组11例(埃索美拉唑镁+枸橼酸铋钾+克拉霉素+益生菌,疗程2周);B组14例(埃索美拉唑镁+枸橼酸铋钾+益生菌,疗程2周,呋喃唑酮1周),停药后4周再次14C尿素呼气试验检测H.pylori,比较2组的H.pylori根除率。结果 A组H.pylori再根除率54.5%(6/11);B组H.pylori再根除率92.9%(13/14),后者高于前者(P<0.01)。结论益生菌联合抗H.pylori治疗可显著提高H.pylori根除率,含呋喃唑酮方案的根除率明显提高。
Objective To investigate the re-eradication program of resistant H. pylori. Methods Twenty-five patients with H.pylori infection who had been treated by two cycles of eradication had a positive urea breath test. Randomized into different treatment groups: A group of 11 patients (esomeprazole magnesium + bismuth potassium citrate + clarithromycin + probiotics, treatment for 2 weeks); B group of 14 patients (esomeprazole magnesium + Bismuth potassium citrate + probiotics, treatment for 2 weeks, furazolidone for 1 week), 14C urea breath test again after 4 weeks of detection of H. pylori H.pylori eradication rate was compared between the two groups. Results The H.pylori re-eradication rate was 54.5% (6/11) in group A; the eradication rate of H.pylori in group B was 92.9% (13/14), the latter was higher than the former (P <0.01). Conclusions Probiotics combined with anti-H.pylori treatment can significantly improve the eradication rate of H.pylori, and the eradication rate of furazolidone-containing regimen is obviously improved.