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目的:探讨心肺复苏(cardio-pulmonary resuscitation,CPR)时肾上腺素最佳给药方式,以提高心肺复苏患者成活率及改善脑功能恢复。方法:选择心搏骤停患者110例,随机分为治疗组52例,对照组58例,所有患者发病后CPR时均迅速建立静脉输液通道,即刻静脉注射肾上腺素1mg,继之治疗组应用电脑微量泵据病情在15min内持续泵入肾上腺素3～5mg;对照组每3～5min据病情重复1mg,共3～5次,2组其他抢救措施相同。结果:2h复苏成功率1)、72h有效存活率2)、存活出院率3)、存活患者残疾率4),治疗组分别为:40.38%、26.92%、19.23%、33.33%,对照组分别为:39.66%、12.07%、8.62%、80.00%。组间比较差异均有统计学意义。结论:电脑微量泵持续泵入给药是CPR时肾上腺素理想的给药方式,能明显改善CPR患者中远期预后,值得在临床CPR时推广。
Objective: To investigate the best adrenaline administration in cardiopulmonary resuscitation (CPR) in order to improve the survival rate of patients with cardiopulmonary resuscitation and improve the recovery of brain function. Methods: One hundred and ten patients with cardiac arrest were randomly divided into treatment group (n = 52) and control group (n = 58). All patients were quickly established after intravenous infusion of CPR, intravenous epinephrine 1mg, followed by treatment group According to the condition, the micro pump continuously pumped into adrenaline 3 ~ 5mg within 15min; the control group repeated 1mg every 3 ~ 5min according to the condition, a total of 3 ~ 5 times, the other two groups of rescue measures were the same. Results: 2 h recovery success rate 1), 72 h effective survival rate 2), survival and discharge rate 3), the survival of patients with disabilities 4), the treatment group were: 40.38%, 26.92%, 19.23%, 33.33% : 39.66%, 12.07%, 8.62%, 80.00%. The differences between the groups were statistically significant. CONCLUSION: Continuous pump-in of computer micropumps is the ideal mode of administration of epinephrine at CPR, which can significantly improve the long-term prognosis of patients with CPR. It is worth to be popularized in clinical CPR.