论文部分内容阅读
本文讨论了药物制剂体内外相关性研究的各种教学处理方法,即函数参数间的相关性计算和线性系统分析法。在函数参数法中讨论了经验参数、代数参数及统计矩参数等内容:线性系数分析法着眼于输入响应之间的直接关系。在分析时用系统的时间特性W(t)联系系统输入和输出端上的有关变量,而不考虑系统内部的情况(即内部的配置状况),仅要求机体必须是线性时不变系统(即体内药物的配置必须服从线性动力学),统计矩和线性系统分析法不仅有可靠的理论依据,而且是普遍适用的处理方法。
This article discusses a variety of teaching approaches for the in vitro and in vivo correlation of pharmaceutical formulations, namely, correlation calculations of function parameters and linear system analysis. The parameters of empirical function, algebraic parameters and statistical moment parameters are discussed in the function parameter method: The linear coefficient analysis focuses on the direct relationship between input responses. The relevant variables on the input and output of the system are linked with the time characteristics of the system W (t) in the analysis, irrespective of the situation inside the system (ie the internal configuration situation), only the body must be linearly invariant (ie In vivo drug placement must be subject to linear dynamics), and statistical moments and linear systems analysis methods have not only proven theoretical bases but also universally applicable treatments.