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目的:观察不同用药方案在慢性鼻窦炎伴鼻息肉患者鼻内镜术后的应用效果。方法:抽取2017年10月至2021年2月驻马店市中心医院收治的慢性鼻窦炎伴鼻息肉患者120例，按随机数字表法分为研究组(60例)与对照组(60例)。两组均行鼻内镜手术，对照组术后应用生理氯化钠溶液冲洗鼻腔并给予糠酸莫米松鼻喷雾剂喷鼻，研究组在对照组治疗基础上采用小剂量罗红霉素治疗。比较两组的临床效果、症状评分、恢复情况、鼻腔结构[鼻腔最小横截面面积(NMCA)、鼻腔容积(NCV)]、鼻气道阻力、嗅觉功能及并发症发生率。结果:研究组总有效率(96.67%，58/60)高于对照组(78.33%，47/60)，n P<0.05。研究组头晕头痛、鼻塞、鼻分泌物评分低于对照组(n P<0.05)。研究组鼻腔黏膜恢复时间和鼻腔通气时间短于对照组(n P<0.05)。术后3个月，研究组NMCA、NCV、嗅觉功能评分高于对照组，鼻气道阻力低于对照组(n P<0.05)。研究组并发症发生率(5.00%，3/60)低于对照组(16.67%，10/60)，n P<0.05。n 结论:慢性鼻窦炎伴鼻息肉患者鼻内镜术后联合应用罗红霉素、糠酸莫米松鼻喷雾剂，可加快术后恢复，减轻临床症状，促进鼻腔结构改善，降低鼻气道阻力，恢复嗅觉功能，并可降低并发症发生率。“,”Objective:To analyze the effects of different medication protocols after endoscopic sinus surgery on patients with chronic sinusitis complicated by nasal polyp.Methods:A total of 120 patients with chronic sinusitis complicated by nasal polyp treated in Zhumadian Central Hospital from October 2017 to February 2021 were selected and divided into study group (60 cases) and control group (60 cases) according to the random number table method. Both groups received endoscopic sinus surgery, while the control group was treated by normal saline flushing and mometasone furoate nasal spray after the operation, and the study group was treated with low-dose roxithromycin based on the treatment of the control group. The clinical effect, symptom scores, recovery condition, nasal structure, including minimum cross-sectional area of nasal cavity (NMCA) and nasal cavity volume (NCV), nasal airway resistance, olfactory function, and complication rate were compared between the two groups.Results:The total effective rate of the study group (96.67%, 58/60) was higher than that of the control group (78.33%, 47/60), n P<0.05. The scores of dizziness, headache, nasal obstruction and nasal secretion of the study group were lower than those of the control group (n P<0.05). The nasal mucosa recovery time and nasal ventilation time of the study group were shorter than those of the control group (n P<0.05). Three months after operation, the NMCA, NCV and olfaction score of the study group were higher than those of the control group, while nasal airway resistance was lower than that of the control group (n P<0.05). The incidence of complications of the study group (5.00%, 3/60) was lower than that of the control group (16.67%, 10/60),n P<0.05.n Conclusions:Roxithromycin combined with mometasone furoate nasal spray, in the treatment of chronic sinusitis with nasal polyps after endoscopic sinus surgery, can accelerate postoperative recovery, alleviate clinical symptoms, promote the improvement of nasal structure, reduce nasal airway resistance, restore olfactory function, and reduce the incidence of complications.