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目的探讨氯吡格雷、阿司匹林联合溶栓治疗急性ST段抬高型心肌梗死的临床效果。方法选取本院自2011年5月~2013年5月收治的76例急性ST段抬高型心肌梗死患者随机分为研究组与对照组,各为38例,给予对照组患者阿司匹林等常规溶栓治疗,研究组患者在此基础上同时采用氯吡格雷治疗,比较两组患者临床治疗效果及不良反应发生情况。结果研究组患者心绞痛复发、复合重点发生率明显低于对照组,P<0.05,差异具有统计学意义;两组患者出血等不良反应差异无统计学意义,P>0.05。结论氯吡格雷、阿司匹林联合溶栓治疗急性ST段抬高型心肌梗死疗效显著,安全性高,可在临床推广使用。
Objective To investigate the clinical effect of clopidogrel and aspirin combined with thrombolysis in the treatment of acute ST-segment elevation myocardial infarction. Methods Seventy-six patients with ST-segment elevation myocardial infarction admitted to our hospital from May 2011 to May 2013 were randomly divided into study group and control group, each with 38 cases. Patients in control group were given routine thrombolysis such as aspirin Treatment, study group patients on this basis, while using clopidogrel treatment, the clinical efficacy of the two groups were compared and the incidence of adverse reactions. Results The recurrence rate of angina pectoris in the study group was significantly lower than that in the control group (P <0.05), and the difference was statistically significant. There was no significant difference in bleeding and other adverse reactions between the two groups (P> 0.05). Conclusion Clopidogrel and aspirin combined with thrombolytic therapy in acute ST-segment elevation myocardial infarction have significant curative effect, high safety and can be used clinically.