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在有机磷杀虫剂中对硫磷(parathion)最常引起急性中毒事件(有许多是致死性病例)和职业性中毒。一般根据出现的症状、血液胆碱酯酶活性、尿中代谢物和血中对硫磷水平进行诊断和治疗,尽管这些指标与临床中毒过程并无良好的相关。在对硫磷急性中毒病人中,常采用血液灌流技术加速清除体内杀虫剂,因而对该杀虫剂毒代动力学的研究将宜于更适当地运用治疗措施。本文用健康新西兰雄性家兔(1.65～2.33kg)作毒代动力学研究,单次静脉注射剂量1.5mg/kg,口服3mg/kg两种途径。血浆经酸化和溶剂抽提后,用Varian 3700气相色谱仪(电子捕获检测器)检测血浆中对硫磷浓度,总回收率94.6％,批内变异系数4.9％,
Of the organophosphorus insecticides, parathion most frequently causes acute poisoning (many are fatal) and occupational poisonings. The symptoms and blood cholinesterase activity, urinary metabolites, and parathion levels in the blood are generally diagnosed and treated based on the symptoms that appear, although these indicators do not correlate well with clinical toxicities. In patients with acute parathion poisoning, hemoperfusion techniques are often used to expedite the removal of insecticides in vivo, and thus the study of the toxicokinetics of the insecticide will be more appropriate for the therapeutic use. In this paper, healthy New Zealand male rabbits (1.65 ~ 2.33kg) for toxicokinetic studies, a single intravenous dose of 1.5mg / kg, oral 3mg / kg two ways. After plasma acidification and solvent extraction, plasma concentrations of parathion were measured by a Varian 3700 gas chromatograph (electron capture detector) with a total recovery of 94.6%, an intra-assay coefficient of variation of 4.9%