【摘 要】
：
The Suzuki-Miyaura reaction of methyl-5-bromo-8-(tosyloxy)-1,6-naphthyridine-7-carboxylate(5),with 2 equiv. of arylboronic acids gave diarylated product, 5,8–d
【机 构】
：
Organic and Medicinal Chemistry Research Laboratory, School of Advanced Sciences, VIT-University,
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
The Suzuki-Miyaura reaction of methyl-5-bromo-8-(tosyloxy)-1,6-naphthyridine-7-carboxylate(5),with 2 equiv. of arylboronic acids gave diarylated product, 5,8–diaryl-1,6-naphthyridine-7-carboxylate(7), whereas 1 equiv. of arylboronic acid resulted in site-selective formation of 5-aryl-8-(tosyloxy)-1,6-naphthyridine-7-carboxylate(8). The reactions proceeded with excellent chemo-selectivity in favor of the bromide group. Likewise, one-pot reaction with completely different boronic acids by sequential addition produced 1,6-naphthyridine-7-carboxylates,(10) containing two different aryl groups at 5 and 8 positions.
The Suzuki-Miyaura reaction of methyl-5-bromo-8- (tosyloxy) -1,6-naphthyridine-7-carboxylate with 5 equiv. Of arylboronic acids gave diarylated product, 6-naphthyridine-7-carboxylate (7), while 1 equiv. Of arylboronic acid resulted in site-selective formation of 5-aryl-8- (tosyloxy) -1,6-naphthyridine- proceeded with excellent chemo-selectivity in favor of the bromide group. (one), with one-pot reaction with completely different boronic acids by sequentially added 1,6-naphthyridine-7-carboxylates, (10) containing two different aryl groups at 5 and 8 positions.
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